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AI agent frameworks for Python

Python libraries for building production agents.

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1LangChain

Open-source LLM application framework — chains, agents, RAG, and 700+ integrations with 127K GitHub stars

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2LlamaIndex

Python RAG framework — connect LLMs to 160+ data sources with production-grade retrieval pipelines

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3CrewAI

Python framework for orchestrating role-playing multi-agent AI teams

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4AutoGen

Microsoft's open-source framework for conversational multi-agent AI systems

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5Semantic Kernel

Microsoft's open-source SDK for AI orchestration — plugins, agents, and LLM integration for C#, Python, and Java

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